Fig. 4.
Effects of PGF2α-treatment on the expression of HIF-1α mRNA isoforms in MDI-treated 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were induced to undergo adipocyte differentiation by the standard MDI protocol in the presence of either vehicle or 100 nM PGF2α for the first 48 h of the culture period. Total RNA was isolated at the indicated number of days post-differentiation and the expression of either the HIF-1α I.1 or HIF-1a I.2 mRNA isoforms, or HPRT was analyzed by RT-PCR analysis. Data are representative of three independent experiments.