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. 2008 Jun;3(6):398–400. doi: 10.4161/psb.3.6.5420

Figure 1.

Figure 1

(A) The Phospholipase D (upper) and C (lower) pathways. Extracellular signaling activates G-protein coupled receptors; heterotrimeric G-proteins then activate PLD and PLC. PLD and PLC synthesize PA as described in the text. Both 1-butanol and 2-butanol disrupt the PLD pathway by mimicking receptor binding, while conversion of DAG to PA can be blocked by R59022, which inhibits DAGK activity. (B) Projection of confocal sections from the nucleus to the cortex of a zygote treated with 20 µM R59022 at 1 h AF, fixed and immunolabeled for MTs at 24 h AF. Scale bar equals 50 µm.