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Transcriptional events in adipogenic differentiation. The diagram highlights the critical role of multiple transcription factors in adipogenesis. Arrows generally indicate a stimulatory interaction (with the exception of TNFα and leptin). After ligand binding with either endogenous ligands or TZD, PPARγ binds as a heterodimer with retinoid X receptor (RXR) to PPAR response elements (PPRE) in the transcriptional regulatory regions of the target genes. Insulin R., Insulin Receptor.
