Table 1.
Ratio of observed and expected allele frequencies for nucleotide polymorphisms
| Allele | Total frequency | Frequency in negative population | Frequency in positive population | Odds ratio | Wald 95% confidence internal |
| 60C | 92.1 | 88.8 | 97.4 | 0.21 | 0.07–0.62 |
| *60T | 7.9 | 11.2 | 2.6 | ||
| 153C | 88.5 | 92.5 | 82.2 | 2.66 | 1.41–5.03 |
| *153T | 11.5 | 7.5 | 17.8 | ||
| 243T | 98.5 | 98.3 | 98.6 | ns | |
| 243A | 1.5 | 1.7 | 1.4 | ||
| 285A | 93.9 | 91.7 | 98.0 | 0.21 | 0.06–0.72 |
| *285C | 6.1 | 8.3 | 2.0 | ||
| 286G | 86.2 | 79.6 | 96.7 | 0.13 | 0.05–0.34 |
| *286A | 13.8 | 20.4 | 3.3 | ||
| 378G | 99.7 | 99.6 | 100 | ns | |
| 378A | 0.3 | 0.4 | 0 | ||
| 438C | 95.7 | 95.0 | 96.7 | ns | |
| 438T | 4.3 | 5.0 | 3.3 | ||
| 555C | 57.6 | 53.8 | 63.8 | 0.66 | 0.43–1.00 |
| *555T | 42.4 | 46.2 | 36.2 | ||
| 676C | 98.7 | 97.9 | 100.0 | ns | |
| 676A | 1.3 | 2.1 | 0 |
Bold text indicates loci where nucleotide sequence resulted in a change of expressed protein; other polymorphisms were synonymous.
*
Indicates a significant association (p < 0.05) between allele and CWD status using chi-square expected frequency for presence/absence of each allele obtained from PROC FREQ. Odds ratios were obtained with PROC LOGISTIC using each allele as a class variable regressed against CWD as an outcome. Only odds ratios with significant (p < 0.05) parameter estimates are reported. Polymorphisms with non-significant odds ratios and 95% confidence limits overlapping 1 are denoted by ns.