Figure 1.

Structures involved in the in vitro conversion of rec PrP(90–231) induced by lowering SDS concentration. The structures analysed within the in vitro conversion system are summarized. Exemplarily for the methods used to analyse these structures, beneath the different intermediates the CD-spectra are shown. Next to the aggregated states the electron micrograph of these structures are shown. The upper part represents the conversion without added NaCl, the lower part with added NaCl, respectively. Modified according to reference ¹⁸.