Table 3.

Sequences and binding affinities of different mutants

aptamers	sequence	Kd (nM)
		bPrP	bPrP-β
apt #1	5′-GGAGGAGGAGGA-3′	31 ± 6	220 ± 67
m1	5′-GGAGGAGGA-3′	79 ± 24	≥1000
m2	5′-GGAGGA-3′	75 ± 28	≥1000
m3	5′-(no GGA repeat)-3′	55 ± 24	≥1000
m4	5′-UUUUUUUUUUUU-3′	134 ± 42	≥1000
m5	5′-UUAUUAUUAUUA-3′	56 ± 16	≥1000