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Comparison of adenine stretch at 5′-site of (GGA)4 with binding affinities of bPrP, bPrP(102–241) and bPrP-β
| aptamers | sequence | Kd (nM) | ||
| bPrP | bPrP (102–241) | bPrP-β | ||
| r(GGA)4-19 | AAAAAAAGGAGGAGGAGGA | 17 ± 5 | 540 ± 310 | 270 ± 90 |
| r(GGA)4-18 | AAAAAAGGAGGAGGAGGA | 10 ± 2 | 160 ± 50 | 150 ± 40 |
| r(GGA)4-17 | AAAAAGGAGGAGGAGGA | 9.4 ± 4.0 | 270 ± 120 | 78 ± 30 |
| r(GGA)4-16 | AAAAGGAGGAGGAGGA | 16 ± 3 | 190 ± 50 | 92 ± 26 |
| r(GGA)4-15 | AAA GGAGGAGGAGGA | 16 ± 4 | 220 ± 90 | 200 ± 90 |
| r(GGA)4 | GGAGGAGGAGGA | 8.5 ± 3.4 | 240 ± 90 | 280 ± 80 |
