Figure 8.

Empirical stability measures for known LHBHs and four model LHBHs. We compare side-chain-to-side-chain hydrogen bonding, volume packing fraction and frustration index (see text for definitions), with a positive frustration index indicating good exposure of hydrophilic residues and burial of hydrophobic residues. The C3,C4 models compare favorably to known left handed LHBH values; N3 does badly on packing and side-chain-to-side-chain hydrogen bonding, while N2 fares better. In addition to 1KGQ and 1MR7 (c.f. Fig. 7) we have compared to 1SSM (Serine Acetyltransferase⁷¹), 1T3D (Serine Acetyltransferase⁷²), 1G97 (N-acetylglucosamine-1-phosphate uridyltransferase⁷³) and 1LXA (UDP-N-acetylglucosamine acyltransferase⁷⁴).