Figure 2.

Synthetic amyloid fibrils made from Aβ peptide (A) electron micrograph showing long, straight, unbranching fibrils. (B) X-ray fiber diffraction pattern from partially aligned amyloid fibrils showing the characteristic “cross-β” diffraction pattern. (C) The structure of the Aβ amyloid fibril interpreted from ssNMR data,⁶⁷ showing the top view of the fiber (i and ii) with side chains (i), showing the importance of side chain packing with in the fiber and as a cartoon (ii). The side view (iii) revealing the β-strands running perpendicular to the fiber axis.