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Models of mature protein fibrils based on Small-Angle X-ray scattering solution data. (A) Human alpha-synuclein fibrils and (B) human insulin fibrils.69 The results suggest that insulin fibrils (B) are formed of three intertwining protofibrils, whereas a-synuclein fibril (A) consist of only one protofibril. Each protofibril is assumed to consist of two intertwining protofilaments. Four and three repeating units are shown for alpha-synuclein and insulin respectively.
