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. 2008 Jul-Sep;2(3):112–117. doi: 10.4161/pri.2.3.7488

Table 1.

Some amyloidoses and their respective precursors and amyloid-ogenic proteins

Disease Precursor protein Amyloid protein
Alzheimer's disease Amyloid precursor protein Aβ peptides
Atrial amyloidosis Atrial natriuretic factor (ANF) Amyloid ANF
Spongiform encephalopathies Prion protein (PrPc) PrPsc
Primary systemic amyloidosis Immunoglobulin light and heavy chains AL and AH
Senile systemic amyloidosis Wild-type transthyretin ATTR
Haemodialysis-related amyloidosis β2-microglobulin Aβ2M
Hereditary nonneuropathic systemic amyloidosis Lysozyme ALys
Type II diabetes Pro-IAPP IAPP or “amylin”
Injection-localized amyloidosis Insulin AIns
Secondary systemic amyloidosis (Apo) serum amyloid A Serum amyloid A
Hereditary cerebral amyloid angiopathy Cystatin C ACys
Finnish hereditary systemic amyloidosis Gelsolin AGel
Familial amyloid polyneuropathy I Transthyretin variants ATTR
Familial amyloid polyneuropathy II Apolipoprotein A1 AApoA1
Ageing pituitary, prolactinomas Prolactin APro
Familial amyloidosis Fibrinogen αA-chain AFib
British familial dementia Amyloid Bri Precursor Protein ABri