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. 2008 Jul-Sep;2(3):123–128. doi: 10.4161/pri.2.3.7437

Figure 4.

Figure 4

Relative PK resistance of PrPSc in prion affected cattle and TgBoPrP mice. (A) PK resistance of PrPSc in the cattle brain of C-BSE and BSE/JP24. (B) PK resistance of PrPSc of TgBoPrP mice inoculated with C-BSE and BSE/JP24 prions. (C) PK resistance of PrPSc from the subsequent passage of C-BSE and BSE/JP24 prion to TgBoPrP mice. The PrPSc concentration of sample was adjusted by the signal intensity of western blotting. The samples were treated with PK of various concentration (40–1,000 µg/ml) at 37°C for 1 h. Data shown represent one of three experiments demonstrating similar trends. PrPSc was detected with mAb 6H4. Molecular markers are shown on the left (kDa).