Table 1.
Inoculum | Mice | No. diseased/no. inoculated | Incubation period (days ± SD) |
C-BSE | |||
1st passage | TgBoPrP | 11/11 | 223.5 ± 13.5 |
2nd passage | TgBoPrP | 15/15 | 214.9 ± 4.8 |
1st passage | ICR | 5/5 | 408.6 ± 28.2 |
BSE/JP24 | |||
1st passage | TgBoPrP | 10/10 | 197.7 ± 3.4* |
2nd passage | TgBoPrP | 10/10 | 152.2 ± 3.1* |
1st passage | ICR | 0/23 | >649** |
The incubation periods were significantly different between the first and second passage of BSE/JP24 prion (p < 0.05).
No PrPSc accumulation was observed at 649 days post inoculation.