Figure 3.

Behavioral analysis of prion inoculated C12 WT and KO mice (n = 6–9 per group). Mice were single housed and video recorded for 24 hours and their behaviors were quantitated by Homecagescan 2.0 software. A similar decrease in the amount of time spent grooming (A) and hanging (B) was observed and a similar dramatic increase in activity as measured by the percent of total time spent walking (C) was observed in C12 WT and KO mice inoculated with prions. Data is shown as mean values plus standard error of the mean. No statistically significant differences (at a threshold of p < 0.05) were observed for grooming, hanging and walking (Wilcoxon rank sum test).