Figure 3.

A diagram of the parameters determining ψ⁺ variant strength and stability: adapted from Figure 1B in Tanaka et al.⁶ Strength is determined by the concentration of monomeric Sup35p: the less there is, the stronger the suppression. In ψ strains that is determined by the growth rate of aggregate (β) relative to the rate of synthesis of Sup35p (α). Stability is related to the numbers of fibres (vertical axis) which is determined by their fragmentation by Hsp104 etc. (γ). Possible position of the variants found by Fernandez-Bellot Figure 2 are suggested. Tanaka et al. suggest “real” positions of the three variants they describe, calculated from their measured parameters of fibre growth (γ), fragility (γ) and number.