Table 1.
Incubation times and survival of scrapie infected mice treated with W3 and preimmune serum
| Experimental Group | Incubation Times, Days (Mean +/- SD) | Survival, Days (mean +/- SD) | Incubation Times + Survival, Days (mean +/- SD) | Number of Mice (Affected/Inoculated) |
| preimmune serum | 169,5 ± 1,2 | 17,5 ± 7,2 | 187,8 ± 10,6 | 6/6 |
| W3 | 171 ± 1,78 | 31,4 ± 16 (1.8-fold increase in survival) | 202,2 ± 18,4 | 5/5 |
LRP/LR antibody W3 and preimmune serum was intraperitoneally injected into C57BL/6 mice (1 mg per week) for a period of 12 weeks. C57BL/6 mice were intraperitoneally inoculated with RML prions one week after the first antibody/preimmune serum injection. Incubation times represent the time span from the day of RML inoculation until one of the four symptoms occur: ataxia of gait, tremor, difficulty righting from a supine position, and occurrence of rigidity in the tail.25 Survival represent the time span from the day one of the four TSE-relevant symptoms occurs until the day mice show two of the four TSE-relevant symptoms over three days.25 At this time point mice were sacrificed.