Table 1.
Summary of Candidate Oncogenes
| Gene Symbol |
Chromosomal Location |
Exons Resequenced |
Primary Tumors Analyzed |
Tumors with Mutations |
RAF/MEK/ERK Pathway |
DNA Gain | Mutated in Other Cancers |
Pigmentation or Melanoma Phenotype |
|---|---|---|---|---|---|---|---|---|
| ARAF | Xp11.4-p11.2 | 9, 12 | 19 | 0 | X | X | ||
| ARHGAP1 | 11p12-q12 | 11 | 19 | 0 | X | X | ||
| DIRAS2 | 9q22.2 | 1 | 19 | 0 | X | |||
| EDG5 | 19p13.2 | 2 | 16 | 0 | X | X | ||
| GEM | 8q13-q21 | 1−3 | 19 | 0 | X | X | ||
| GNAQ | 9q21 | 5 | 67 | 36 | X | X | X | |
| GRM1 | 6q24 | 1−8 | 16 | 0 | X | X | ||
| LYN | 8q13 | 12 | 19 | 0 | X | X | X | |
| MAPK13 | 6p21.31 | 1−11 | 19 | 0 | X | X | X | |
| MAPK14 | 6p21.3-p21.2 | 1−9 | 19 | 0 | X | X | X | |
| PAK7 | 20p12 | 10 | 19 | 0 | X | X | X | |
| PIK3R1 | 5q13.1 | 8 | 19 | 0 | X | X | ||
| PIP5KL1 | 9q34.11 | 3 | 19 | 0 | X | X | ||
| PSKH2 | 8q21.2 | 2 | 19 | 0 | X | X | X | |
| PTK2 | 8q24-qter | 19 | 19 | 0 | X | X | X | |
| PTK6 | 20q13.3 | 1, 7 | 19 | 0 | X | X | X | |
| PTPN11 | 12q24 | 3−4, 13 | 16 | 0 | X | X | X | |
| RAB2 | 8q12.1 | 1, 2, 4 | 19 | 0 | X | X | ||
| RAB23 | 6p11 | 2−6 | 19 | 0 | X | X | ||
| RAB22A | 20q13.32 | 1−3 | 19 | 0 | X | X | ||
| RAF1 | 3p25 | 6, 9 | 19 | 0 | X | X | ||
| RAPGEF1 | 9q34.3 | 19 | 19 | 0 | X | X | ||
| RASIP1 | 19q13.33 | 3 | 19 | 0 | X | |||
| REM1 | 20q11.21 | 1−3 | 19 | 0 | X | X | X |