Table 4. Relationship between epithelial marker and uPAR expression in bone marrow and peripheral blood and clinicopathologic findings.
Epithelial marker and uPAR expression in BM
|
Epithelial marker and uPAR expression in PB
|
||||||
---|---|---|---|---|---|---|---|
Both positive | Others | Both positive | Others | ||||
Total (n=846) | n=126 | n=720 | P-value | n=200 | n=646 | P-value | |
Age (mean±s.d.*) | 60.9±0.97 | 61.6±0.43 | NS | 60.8±0.81 | 61.7±0.45 | NS | |
Gender | 0.403 | ||||||
Male | 567 | 88 (69.8) | 479 (66.5) | 130 (65.0) | 437 (67.6) | 0.526 | |
Female | 279 | 38 (30.2) | 241 (33.5) | 70 (35.0) | 209 (32.4) | ||
Histology | 0.645 | ||||||
Differentiated | 188 | 30 (23.8) | 158 (21.9) | 45 (22.5) | 143 (22.1) | 0.914 | |
Undifferentiated | 658 | 96 (76.2) | 562 (78.1) | 155 (77.5) | 503 (77.9) | ||
pT | 0.183 | ||||||
pT1/T2 | 657 | 92 (73.0) | 565 (78.5) | 147 (73.5) | 510 (79.0) | 0.11 | |
pT3/T4 | 189 | 34 (27.0) | 155 (21.5) | 53 (26.5) | 136 (21.0) | ||
pN | 0.012 | ||||||
pN0 | 496 | 61 (48.4) | 435 (60.4) | 112 (56.0) | 384 (59.4) | 0.389 | |
pN1 | 350 | 65 (51.6) | 285 (39.6) | 88 (44.0) | 262 (40.6) | ||
pM (Distant metastasis) | 0.108 | ||||||
pM0 | 743 | 105 (83.3) | 638 (88.6) | 170 (85.0) | 573 (88.7) | 0.171 | |
pM1 | 103 | 21 (16.7) | 82 (11.4) | 30 (15.0) | 73 (11.3) | ||
Postoperative recurrence | 0.145 | ||||||
Non recurrence | 833 | 122 (96.8) | 711 (98.8) | 197 (98.5) | 636 (98.5) | 0.961 | |
Recurrence | 13 | 4 (3.2) | 9 (1.2) | 3 (1.5) | 10 (1.5) | ||
Lymphatic invasion | 0.009 | ||||||
Negative | 486 | 59 (46.8) | 427 (59.3) | 117 (58.5) | 369 (57.1) | 0.73 | |
Positive | 360 | 67 (53.2) | 293 (40.7) | 83 (41.5) | 277 (42.9) | ||
Venous invasion | 0.102 | ||||||
Negative | 702 | 98 (77.8) | 604 (83.9) | 162 (81.0) | 540 (83.6) | 0.399 | |
Positive | 144 | 28 (22.2) | 116 (16.1) | 38 (19.0) | 106 (16.4) | ||
Stage | 0.024 | ||||||
I, II | 634 | 84 (66.7) | 550 (76.4) | 141 (70.5) | 493 (76.3) | 0.101 | |
III, IV | 212 | 42 (33.3) | 170 (23.4) | 59 (29.5) | 153 (23.7) |
*s.d.=standard deviation.