Table 2. Associations between HER2 gene amplification or EGFR expression and disease characteristics including type of histology, FIGO stage, and grade.
|
Patients
|
HER2-positive
|
EGFR-positive
|
||||
|---|---|---|---|---|---|---|
| No. | Valid % | No. | Valid % | No. | Valid % | |
| Histology* | ||||||
| Endometrioid grade 1 | 51 | (18) | 1/50 | (2) | 27/48 | (56) |
| Endometrioid grade 2 | 54 | (20) | 1/53 | (2) | 22/47 | (47) |
| Endometrioid grade 3 | 40 | (15) | 0/40 | (0) | 11/35 | (31) |
| Clear cell | 28 | (10) | 4/25 | (16) | 6/24 | (25) |
| Serous papillary | 106 | (37) | 18/105 | (17) | 36/101 | (36) |
| FIGO stage** | ||||||
| I | 140 | (52) | 8/140 | (6) | 54/127 | (43) |
| II | 11 | (4) | 0/11 | (0) | 4/9 | (44) |
| III | 46 | (17) | 3/46 | (7) | 14/43 | (33) |
| IV | 77 | (27) | 13/77 | (17) | 27/72 | (38) |
| Grade*** | ||||||
| 1 | 54 | (21) | 1/54 | (2) | 28/51 | (55) |
| 2 | 59 | (23) | 2/59 | (3) | 23/52 | (44) |
| 3 | 148 | (56) | 17/148 | (11) | 45/138 | (33) |
Unknown data: grade (n=17), stage (n=4), HER2 (n=6), EGFR (n=24).
* χ2 test type I versus type II: P<0.001 for HER2, and P=0.041 for EGFR.
** χ2 test: P=0.025 for HER2, and P=0.667 for EGFR.
*** χ2 test: P=0.028 for HER2, and P=0.016 for EGFR.