Table 8. A comparison of toxicities among a variety of chemotherapy regimens within four clinical trials in which cetuximab was used.

	XELOX a	OxMdG a	FOLFOX b	XELOX b	FOLFIRI c	FOLFOX-4 d	Cetuximab+ XELOX a	Cetuximab+ OxMdG a	Cetuximab+ FOLFIRI c	Cetuximab+ FOLFOX-4 d
N	333	203	649	655	602	168	166	102	600	170
Any grade 3 or 4 toxicity	35	35	78.3	71.5	59.5	NS	57	63	78.0	NS
Neutropaenia	2	17	43.8	7.0	23.3	31.5	1	26	26.7	27.6
Nausea or vomiting	7	3	NS	NS	5.0	NS	14	7	4.5	NS
Diarrhoea	15	6	11.2	20.2	10.5	6.0	25	13	15.2	7.1
Skin rash	1	0	NS	NS	0.2	0	10	12	18.7	14.1
Hypersensitivity			NS	NS	0	1.8			2.3	4.1
										2.0
Lethargy	8	7	NS	NS	4.5	3.0	17	21	5.0	3.5

^aCOIN TRIAL.

^bRoche N966.

^cCrystal trial.

^dOPUS trial.