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. 2008 Nov 11;100(2):240–245. doi: 10.1038/sj.bjc.6604771

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Copyright © 2009 Cancer Research UK

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Working model for transition of bivalent stem cell chromatin to inactive chromatin during cancer development. In stem cells, chromatin exists in a bivalent state characterised by the absence of DNA methylation and the presence of both activating (e.g., H3K4me2) and inactivating (H3K27me3) markers. During cancer development, it is proposed that recruitment of DMNTs through EZH2 causes methylation of DNA. The inactive chromatin is characterised by the markers H3K9me2, H3K9me3, and H3K27me3. Model taken from the data presented by Ohm et al (2007) and Schlesinger et al (2007).