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. 2008 Nov 11;100(2):240–245. doi: 10.1038/sj.bjc.6604771

Table 1. Genes showing frequent hypermethylation in human prostate cancer.

Gene Hormone receptors Cell-cycle control Repair or avoidance of DNA damage Signal transduction Cell adhesion and basement membrane Inflammation response Suppressor or candidate tumour suppressor Unmethylated in human ES cells (Ohm et al, 2007)
APC             √ √
RBP1 (CRBP1)             √ √
CAV1                
CCND2 (cyclin D)   √         √ √
CD44         √      
CDH2         √     √
CDKN2A (INK4a)   √         √ √
DAB2IP       √     √  
DAPK       √     √ √
EDNRB       √        
ESR1 √              
ESR2 √              
FHIT             √  
GSTP2     √       √ √
HIC2             √ √
LAMA3         √      
LABM3         √      
MDR1     √          
0 6− MGMT     √       √ √
PTGS2           √    
RAR-β √           √ √
RASSF1       √     √ √
SFPR1             √ √
TIMP-3             √ √
TMS-1 (PYCARD)             √ √

ES=embryonic stem.

The gene functions are shown. Many have tumour suppressor or potential tumour suppressor functions, and those genes shown by Ohm et al (2007) to be unmethylated in human ES cells are shown.