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. 2009 Jan 6;100(2):412–420. doi: 10.1038/sj.bjc.6604820

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Copyright © 2009 Cancer Research UK

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Forest plots of the study-specific and summary-relative risk and 95% confidence intervals for the association between ovarian cancer risk and three SNPs in the CYP3A4, LIG4 and XRCC2 genes. (A) rs2740574 in CYP3A4. The overall summary ovarian cancer risk among heterozygous carriers is 1.07 (0.85–1.34, P=0.57) and homozygous carriers is 2.81 (95% CI 1.20–6.56, P=0.017). (B) rs1805386 in LIG4. The overall summary ovarian cancer relative risk among heterozygous carriers is 1.01 (95% CI 0.91–1.12, P=0.82) and homozygous carriers is 0.94 (95% CI 0.71–1.25, P=0.68). (C) rs3218536 in XRCC2. The overall summary ovarian cancer relative risk among heterozygous carriers is 0.97 (95% CI 0.88–1.08, P=0.61) and homozygous carriers 0.68 (95% CI 0.42–1.09, P=0.11).