Table 1. Characteristics of the OCAC case–control studies included in this report.
| Study (Ref)a | Location | Years conducted | Control ascertainment | Case ascertainment | No. of controls/cases | SNPs genotyped |
|---|---|---|---|---|---|---|
| ACS | Australia | 2002–2005 | Randomly selected from Commonwealth electoral roll. Frequency matched for age and geographical region. | Cancer registries of New South Wales and Victoria. | 364/166 | rs2740574 (CYP3A4), rs1805386 (LIG4) |
| AOCS (Beesley et al, 2007) | Australia | 2002–2006 | Randomly selected from Commonwealth electoral roll. Frequency matched for age & geographical region. | Recruited through surgical treatment centres throughout Australia and cancer registries of Queensland, South Australia and West Australia. | 698/558 | rs2740574 CYP3A4), rs1805386 (LIG4), rs3218536 (XRCC2), rs861539 (XRCC3) |
| DOVE | Washington, USA | 2002–2005 | Random-digit dial identification from study area. Frequency matched to cases for race/ethnicity and 5-year age group. | Cases diagnosed with primary invasive ovarian cancer between 2002–2005 from a 13-county area of western Washington state. | 744/548 | rs3218536 (XRCC2) |
| GEOCS (Auranen et al, 2005) | Northern California, USA | 1997–2002 | Random-digit dial identification from study area. Frequency matched to cases for 5-year age group and race/ethnicity. | Greater Bay Area Cancer Registry, San Francisco. | 419/317 | rs1805386 (LIG4), rs3218536 (XRCC2), rs861539 (XRCC3) |
| HAWAII (Goodman et al, 2001a, 2001b) | Hawaii, USA | 1993 onwards | Randomly selected from Hawaii Department of Health Annual Survey of the representatives households. | Rapid case ascertainment through Hawaii Tumour Registry. | 160/70 | rs4680 (COMT), rs4646903 (CYP1A1), rs1048943 (CYP1A1), rs1056836 (CYP1B1), rs2740574 (CYP3A4), rs743572 (CYP17), rs3020450 (ESR2), rs3218536 (XRCC2) |
| HOPE | NY, OH and PA, USA | 2003 onwards | Identified in same regions. Frequency matched for age and ethnicity. | Physician offices, cancer registries and pathology databases from counties of western PA, eastern OH and western NY. | 662/297 | RS3218536 (XRCC2) |
| MALOVA (Auranen et al, 2005) | Denmark | 1994–1999 | Random sample of general female population (35–79 years of age) in study area. Selected using computerised Central Population Register and matched to cases for age and geographical region. | Incident cases (35–79 years of age) from municipalities of Copenhagen and Frederiksberg and surrounding counties. | 1197/42 | rs2740574 (CYP3A4), rs1805386 (LIG4), rs3218536 (XRCC2), rs861539 (XRCC3) |
| MAYO (Sellers et al, 2005) | Mayo Clinic, USA | 2000 onwards | Healthy women seeking general medical examination identified through Mayo Clinic. Frequency matched to cases for age, race, and state of residence. | Cases attending Mayo Clinic identified in a six-state surrounding region. | 442/325 | rs4680 (COMT), rs1048943 (CYP1A1), rs1056836 (CYP1B1), rs3218536 (XRCC2) |
| NCOCS | North Carolina, USA | 1999 onwards | Controls identified from same region. Frequency matched to cases for age and race. | Identified from 48 counties within the region by rapid-case ascertainment. | 941/702 | rs2740574 (CYP3A4), rs743572 (CYP17), rs3020450 (ESR2), rs1805386(LIG4), rs3218536(XRCC2), rs861539 (XRCC3) |
| NECC (Garner et al, 2002; Terry et al, 2003) | New England, USA | 1992–2003 | Controls identified through random digit dialing, townbooks, and drivers’ license lists. Frequency matched to cases on age and state of residence. | Identified through hospital tumour boards and state cancer registries in New Hampshire and Massachusetts. | 484/268 | rs4646903 (CYP1A1), rs1048943 (CYP1A1), rs743572 (CYP17), rs3020450 (ESR2) |
| OVCARE (Holt et al, 2007) | Washington, USA | 1994–1998 | Controls identified through random digit dialing in same three geographic regions as cases. | Incident cases (35–54 years of age) identified by SEER population-based cancer registries serving metropolitan Atlanta, Detroit, and Seattle areas. | 577/188 | rs4680 (COMT), rs4646903 (CYP1A1), rs1048943 (CYP1A1), rs1056836 (CYP1B1) |
| SEARCH (Auranen et al, 2005) | UK | 1991 onwards | Selected from the EPIC-Norfolk cohort of 25,000 individuals aged 45–74, based in the same geographical regions as cases. | Caese<70 years from East Anglian, West Midlands & Trent regions of England. Prevalent cases diagnosed 1991–1998; incident cases diagnosed 1998 onwards. | 1221/851 | rs1805386 (LIG4), rs3218536 (XRCC2), rs861539 (XRCC3) |
| SWH (Spurdle et al, 2002; Webb et al, 2005) | Australia | 1985–1996 (cases) 1992 1993 (controls) | From national twin study (one member of pairs of monozygotic twins). | Cancer registries of New South Wales and Queensland, Australia. | 275/377 | rs2740574 (CYP3A4), rs743572 (CYP17), rs3218536 (XRCC2), rs861539 (XRCC3) |
| UCI | Orange and San Deigo counties, USA | 1994–2004 | Controls identified through random digit dialing. Frequency matched to cases by age group and race/ethnicity. | Recruitment of cases was done by rapid case ascertainment through the Cancer Surveillance Program of Orange and San Diego Counties that resides at UCI and is part of the California Cancer Registry. | 438/298 | rs3218536 (XRCC2) |
| UKOPS | UK | 2006 onwards | Postmenopausal women from the general population participating in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). All women followed up for cancers through the Office of National Statistics | Incident cases from ten gynaecological oncology National Health Service centres throughout the UK, from January 2006 onwards. | 584/262 | rs2740574 (CYP3A4), rs3218536 (XRCC2) |
| USC (Pearce et al, 2008b) | Los Angeles, USA | 1993 onwards | Neighborhood recruited controls, frequency matched to cases for age and ethnicity. | Rapid case ascertainment through Los Angeles Cancer Surveillance Program. | 701/564 | rs743572 (CYP17), rs3020450 (ESR2), rs1805386 (LIG4), rs3218536 (XRCC2) |
a
See Materials and Methods for full study name.