Table 2. Summary odds ratio (per allele) and 95% confidence interval for risk of invasive epithelial ovarian cancer among the indicated OCAC studies for SNPs that showed no association with ovarian cancer.
| Gene | SNP | Controls (N) | Cases (N) | ORheta (95% CI) | P-value | ORhoma (95% CI) | P-value | Studies |
|---|---|---|---|---|---|---|---|---|
| COMT | rs4680 | 874 | 381 | 1.01 (0.75–1.36) | 0.96 | 1.00 (071–1.42) | 0.98 | HAWAII, MAYO OVCARE |
| CYP1A1 | rs4646903 | 1182 | 490 | 1.15 (0.89–1.50) | 0.29 | 0.77 (0.28–2.13) | 0.61 | HAWAII, NECC, OVCARE |
| CYP1A1 | rs1048943 | 1308 | 611 | 1.13 (0.79–1.63) | 0.50 | — | 0.97 | HAWAII, MAYO, NECC, OVCARE |
| CYP1B1 | rs1056836 | 875 | 384 | 0.91 (0.69–1.21) | 0.52 | 0.83 (0.58–1.19) | 0.31 | HAWAII, MAYO OVCARE |
| CYP17 | rs743572 | 1594 | 1078 | 1.09 (0.91–1.30) | 0.36 | 1.19 (0.93–1.52) | 0.17 | HAWAII, NCOCS, NECC, SWH, USC |
| ESR2 | rs3020450 | 2198 | 1523 | 0.95 (0.83–1.10) | 0.52 | 1.09 (0.87–1.36) | 0.44 | HAWAII, NCOCS, NECC, USC |
| XRCC3 | rs861539 | 5186 | 2352 | 0.92 (0.82–1.04) | 0.17 | 1.01 (0.85–1.19) | 0.95 | AOCS, MALOVA, NCOCS, SEARCH, GEOCS, SWH |
a
CI=confidence interval; het=heterozygous carriers; hom=homozygous carriers; OR=odds ratio. All ORs stratified on study site, race/ethnicity and age.