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. 2009 Jan 6;100(2):412–420. doi: 10.1038/sj.bjc.6604820

Table 3. Summary odds ratio and 95% confidence interval for risk of invasive epithelial ovarian cancer among OCAC studies for the three SNPs associated with risk of ovarian cancer in original data.

        95% CI P-value      
  Controls (N) Cases (N) ORheta CYP3A4 rs2740574b ORhoma 95% CI P-value
Original data 664 563 1.51 0.85–2.40 0.084 3.66 1.29–10.40 0.015
Replication data 2827 1406 0.96 0.73–1.25 0.75 2.50 0.54–11.54 0.24
Combined data 3491 1969 1.07 0.85–1.34 0.57 2.81 1.20–6.56 0.017
        LIG4 rs1805386c      
Original data 2196 1630 1.21 1.04–1.40 0.013 1.34 0.90–1.99 0.15
Replication data 2944 1691 0.87 0.75–1.00 0.046 0.67 0.45–1.01 0.056
Combined data 5140 3321 1.01 0.91–1.12 0.82 0.94 0.71–1.25 0.68
        XRCC2 rs3218536d      
Original data 3668 2763 0.92 0.79–1.06 0.24 0.60 0.31–1.17 0.13
Replication data 4005 2551 1.05 0.91–1.21 0.50 0.79 0.40–1.57 0.50
Combined data 7673 5314 0.97 0.88–1.08 0.61 0.68 0.42–1.09 0.11
a

het=heterozygous carriers; OR=odds ratio; hom=homozygous carriers.

b

Studies included in original data: HAWAII, NCOCS, SWH; studies included in follow-up data: ACS, AOCS, MALOVA, UKOPS.

c

Studies included in original data: GEOCS, NCOCS, SEARCH; studies included in follow-up data: ACS, AOCS, MALOVA, USC.

d

Studies included in original data: AOCS, GEOCS, MALOVA, NCOCS, SEARCH, SWH; studies included in follow-up data DOVE, HAWAII, HOPE, MAYO, SEARCH (additional accrued cases), UCI, UKOPS, USC.