Table 4. Odds ratios and 95% CIs by race/ethnicity and histological sub-typea for the CYP3A4 rs2740574 variant in the combined dataset.
| Characteristics | Cases | Controls | ORhetb | 95% CI | P-value | ORhomb | 95% CI | P-value |
|---|---|---|---|---|---|---|---|---|
| Black | 24 | 36 | 2.86 | 0.28–29.63 | 0.38 | 6.82 | 0.73–63.86 | 0.093 |
| White | 1944 | 3453 | 1.06 | 0.84–1.33 | 0.62 | 2.4 | 0.67–8.68 | 0.18 |
| Endometrioid | 229 | 3491 | 1.65 | 1.05–2.59 | 0.03 | 2.64 | 0.36–19.16 | 0.34 |
| Mucinous | 107 | 3491 | 0.54 | 0.19–1.51 | 0.24 | 4.75 | 0.47–47.84 | 0.19 |
| Serous | 1052 | 3491 | 0.93 | 0.70–1.24 | 0.63 | 2.8 | 1.00–7.83 | 0.050 |
a
Clear cell histology not informative.
b
OR=odds ratio; het=heterozygous OR; hom=homozygous OR. Studies included: ACS, AOCS, HAW, MALOVA, NCO, SWH, UKOPS; all ORs stratified on study site, age and race/ethnicity (for histology analyses).