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. 2008 Dec 23;100(2):389–398. doi: 10.1038/sj.bjc.6604846

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Copyright © 2009 Cancer Research UK

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Cyclopamine treatment in mouse primary culture of the gastric epithelial cells. (A) In mice as well as in humans, not only Hh-downstream targets (Gli1 and Gli2) but also EMT regulators (Sip1, Snai2, and Twist2) are downregulated by cyclopamine treatment. (B) Quantitative real-time RT–PCR analyses show the same results of the above conventional RT–PCR. Results were calculated as mean+s.d. values from triplicate measurements of three separate experiments. (C) Other mesenchymal-related genes (Cdh2, Pdgfrb, Ednra, Robo1, Wnt5a, Ror2, Mef2c, and Smtn) are also downregulated by cyclopamine treatment. As a control, Actb is shown in Figure 5A.