Table 2. OS and PFS according to MMR status with the number of events in italic.

Number of patients	PMMR (n=497)	dMMR MLH1 hypermethylation (n=13)	dMMR total (n=18)	P-value# pMMR vs dMMR hypermethylation	P-value# pMMR vs dMMR total
Overall survival (months)
Median (95% CI)	17.9 (16.2–18.9)	7.4 (3.7–16.9)	10.2 (5.9–19.8)	0.27	0.41
	n=440	n=11	n=15
Sequential treatment	17.2 (14.7–18.8)	12.4 (3.2––>)	12.7 (7.4–22.2)	0.58	0.47
Median (95% CI)	n=230	n=4	n=7
Combination treatment	18.3 (16.2–20.6)	6.2 (3.6–31.3)	6.2 (3.6–31.3)	0.25	0.58
Median (95% CI)	n=210	n=7	n=8
PFS (months)
Median (95% CI)	6.9 (6.3–7.7)	4.3 (2.4–6.6)	4.0 (2.3–6.5)	0.85	0.28
	n=490	n=12	n=17
Sequential treatment	5.8 (4.9–6.3)	6.6 (2.2–->)	4.2 (2.2–10.6)	0.27	0.72
Median (95% CI)	n=247	n=4	n=7
Combination treatment	8.3 (7.6–8.7)	4.0 (2.3–6.5)	4.0 (2.3–6.5)	0.06	0.02
Median (95% CI)	n=243	n=8	n=10

^#P-value Cox regression.