Table 3. Prostate cancer genotype specific risk for two SNPs in BRIP1/FANCJ genomic region.
GG | TG | TT | Per allele OR (95% CI) | OR Hom (95% CI) | OR Het (95% CI) | P Het | P trend | |
---|---|---|---|---|---|---|---|---|
rs6504074 | ||||||||
Familial | 345 | 274 | 64 | 1.20 (1.04–1.37) | 1.57 (1.13–2.17) | 1.13 (0.94–1.35) | 0.21 | 0.01 |
Young | 618 | 453 | 87 | 1.07 (0.94–1.20) | 1.19 (0.89–1.59) | 1.04 (0.89–1.21) | 0.62 | 0.28 |
All | 963 | 727 | 151 | 1.11 (1.00–1.23) | 1.33 (1.03–1.71) | 1.07 (0.94–1.23) | 0.32 | 0.04 |
Control | 1031 | 727 | 122 | |||||
rs8076727 | ||||||||
Familial | 373 | 261 | 46 | 1.20 (1.04–1.38) | 1.39 (0.96–2.00) | 1.21 (1.01–1.46) | 0.04 | 0.01 |
Young | 658 | 432 | 72 | 1.12 (1.00–1.27) | 1.23 (0.90–1.69) | 1.14 (0.98–1.33) | 0.10 | 0.06 |
All | 1031 | 693 | 118 | 1.13 (1.03–1.28) | 1.29 (0.97–1.70) | 1.17 (1.017–1.336) | 0.03 | 0.01 |
Control | 1124 | 648 | 100 |
OR=odds ratio; SNP=single nucleotide polymorphism.