Table 2. Grade 3/4 haematological toxicity, treatment delays and additional G-CSF in the four randomised arms.

Toxicity	Standard AC	Accelerated AC	Standard EC	Accelerated EC	Significance (AC vs EC)	Significance (standard vs accelerated)
Anaemia
Grade 3	0	3 (7%)	0	0	P=0.3	P=0.1
Grade 4	0	1 (2%)	0	0
Leucopenia
Grade 3	1 (2%)	0	1 (5%)	0	P=1.0	P=0.2
Grade 4	0	0	0	0
Neutropenia
Grade 3	2 (5%)	0	2 (11%)	0	P=0.4	P=0.01
Grade 4	1 (2%)	0	1 (5%)	0
Thromobocytopenia
Grade 3	0	1 (2%)	0	0	P=1.0	P=1.0
Grade 4	0	0	0	0
Treatment delays:
1 week	3 (7%)	2 (5%)	1 (5%)	3 (13%)	P=0.5	P=0.5
2 weeks	0	1 (2%)	0	1 (4%)
Additional GCSF:
	10 (24%)	3 (13%)	3 (16%)	1 (4%)	P=0.4	P=0.02