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. 2009 Feb 6;4(2):e4384. doi: 10.1371/journal.pone.0004384

Table 5. Heterologous response (A/turkey/Turkey/1/05 − NIBRG-23) following immunisation with MF59-adjuvanted H5N1 subunit influenza vaccine.

Assessment Parameter 7.5 μg HA 15 μg HA
Adult HI n = 70 n = 79
Post-second injection (day 43) GMT 18 (13–24) (n = 69) 14 (10–19) (n = 78)
Seroprotection rate % 36 (25–49) 28 (19–40)
Post-booster injection (day 223) GMT 58 (39–86) 46 (31–67)
Seroprotection rate % 70 (58–80) 59 (48–70)
MN n = 70 n = 81
Post-second injection (day 43) GMT 19 (15–24) 19 (15–24)
Titer ≥40 % 27 (17–39) 21 (13–31)
Post-booster injection (day 223) GMT 77 (60–100) 93 (74–118)
Titer ≥40 % 73 (61–83) 79 (69–87)
SRH n = 70 n = 81
Post-second injection (day 43) GMA 23 (19–28) 24 (20–28)
Seroprotection rate % 70 (58–80) 70 (59–80)
Post-booster injection (day 223) GMA 30 (26–36) 34 (29–39)
Seroprotection rate % 83 (72–91) 88 (78–94)
Elderly HI n = 36 n = 26
Post-second injection (day 43) GMT 14 (8.4–22) 13 (7.74–23) (N = 23)
Seroprotection rate % 36 (21–54) 35 (16–57)
Post-booster injection (day 223) GMT 36 (19–68) 49 (25–97)
Seroprotection rate % 67 (49–81) 65 (44–83)
MN n = 37 n = 26
Post-second injection (day 43) GMT 12 (9.4–16) 17 (13–23)
Titer ≥40 % 11 (3–25) 31 (14–52)
Post-booster injection (day 223) GMT 44 (29–67) 61 (39–95)
Titer ≥40 % 62 (45–78) 65 (44–83)
SRH n = 37 n = 26
Post-second injection (day 43) GMA 15 (9.91–22) 24 (16–36)
Seroprotection rate % 57 (39–73) 77 (56–91)
Post-booster injection (day 223) GMA 24 (17–34) 33 (23–48)
Seroprotection rate % 78 (62–90) 88 (70–98)

Numbers in parenthesis are two-sided 95% confidence intervals; GMT/GMA, geometric mean titer/geometric mean area ;Seroprotection rate = SRH ≥25mm2 or MN ≥40.