Table 4.

A multivariable model to examine to factors associated with quality control pathology-diagnosed cervical intraepithelial neoplasia grade 3 (CIN3) or worse for women with enrollment clinical center cytology of high-grade squamous intraepithelial lesion (HSIL).

	N	%	OR	95%CI
CC Cytology
HSIL-CIN2 (ref)	338	86.4%	1.0
HSIL-CIN3	53	13.6%	3.3	1.0–11
HPV Status
HPV Neg/LR HPV	26	46.5%	0.18	0.046–0.68
HR HPV (ref)	182	6.6%	1.0
HPV16	183	46.8%	4.0	2.2–7.3
Colposcopic Impression
<Low-Grade (ref)	210	53.7%	1.0
≥Low-Grade	181	46.3%	3.3	1.8–6.0
QC Cytology = ASC-H/HSIL
No (ref)	116	29.7%	1.0
Yes	275	70.3%	2.5	1.3–4.6
Smoking Status
Never (ref)	152	38.9%	1.0
Former	39	10.0%	2.3	0.85–6.0
Current, <4 pack-years	90	23.0%	1.4	0.67–2.9
Current, ≥4 pack-years	110	28.1%	2.3	1.1–4.7
Center
Center 1 (ref)	67	17.1%	1.0
Center 2	112	28.6%	0.24	0.086–0.65
Center 3	48	12.3%	0.47	0.15–1.5
Center 4	164	41.9%	0.28	0.11–0.70
Study Arm
IC (ref)	151	38.6%	1.0
HPV	93	23.8%	0.43	0.21–0.89
CM	147	37.6%	0.76	0.39–1.5

OR, Odds ratios; 95%CI, 95% confidence intervals; LSIL, low-grade squamous intraepithelial lesion; HPV, human papillomavirus; HR, high-risk; ASC-H, atypical squamous cells, cannot rule out HSIL

Of the 411 women with HSIL cytology included in this analysis, 391 (95.1%) had complete data and were included in the model.