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. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Oct 2;18(22):5971–5974. doi: 10.1016/j.bmcl.2008.09.103

Figure 3.

Figure 3

Rhodamine uptake results for compounds 1 (paclitaxel), C10 and C7 acids (3, 11, 18 and 23), C10 and C7 esters (7 and 19), C10 and C7 primary amides (8, 12, 20 and 24), C10 and C7 secondary amides (9, 13, 21, and 25), and C10 and C7 tertiary amides (10, 14, 22, and 26) in BMEC’s. Paclitaxel and the derivatives were present at a concentration of 10 µM. The concentration of rhodamine was 5µM. C = control. Compounds that significantly increase rhodamine 123 uptake are show as red bars. Compounds causing decreased or limited rhodamine 123 uptake are shown in blue.