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. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Oct 2;18(22):5971–5974. doi: 10.1016/j.bmcl.2008.09.103

Figure 4.

Figure 4

Calculations of cross-sectional areas, AD and LogD values at pH 7.4 for paclitaxel and analogues. X = Paclitaxel, ∆ = CO2H, ▼ = CO2Me, ◊ = CONH2, ○ = CONHMe, ● = CONHMe, □ = CONMe2, ■ CONMe2 (filled symbols = Pgp substrates).