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. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Oct 2;18(22):5971–5974. doi: 10.1016/j.bmcl.2008.09.103

Scheme 1.

Scheme 1

Synthesis of C10-modified TX-67 analogs. Reagents and conditions: (a) succinic anhydride, DMAP, toluene 85 °C; (b) glutaric anhydride, DMAP, toluene 85 °C; (c) CH2N2, THF; (d) NH4HCO3, THF, BOC2O, pyridine; (e) NH2Me HCl, EDCI, NMM, CH2Cl2; (f) NHMe2 HCl, EDCI, NMM, CH2Cl2; (g) HF-pyridine, pyridine.