Skip to main content
. Author manuscript; available in PMC: 2009 Nov 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Oct 2;18(22):5971–5974. doi: 10.1016/j.bmcl.2008.09.103

Scheme 2.

Scheme 2

Synthesis of C7 TX-67 analogs.19 Reagents and conditions: (a) succinic anhydride, DMAP, toluene 85 °C; (b) glutaric anhydride, DMAP, toluene 85 °C; (c) MeOH, EDCI, DMAP; (d) NH4HCO3, THF, BOC2O, pyridine; (e) NH2Me HCl, EDCI, NMM, CH2Cl2; (f) NHMe2.HCl, EDCI, NMM, CH2Cl2; (g) HF-pyridine, pyridine.