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. 2009 Feb 3;7(2):e1000029. doi: 10.1371/journal.pbio.1000029

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Embryos were treated with either (a and b) DMSO (Control) or (e and f) SB-431542 (5 μM) and analyzed by WMISH to detect (a and e) z13 at 26 h and (b and f) foxA at 26 h . The same mRNAs were detected in embryos injected either with (c and d) buffer or (g and h) ActBMO1 (1.2 mM) at 26 h (c, g, d, and h). The late accumulation of each of these transcripts in vegetal blastomeres was independent of ALK4/5/7 (e and f vs. a and b) and ActivinB (g and h vs. c and d) function at the stages assayed. Images are representative of the molecular phenotypes observed in more than 80% of a minimum of 50 embryos in each of three separate experiments.

(B) Fate map of blastula-mesenchyme blastula stage embryo.