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. 2009 Feb 2;106(6):1971–1976. doi: 10.1073/pnas.0809158106

Fig. 6.

Fig. 6.

Protection by insulin requires IR tyrosine kinase activity. (A–C) Representative images from hippocampal neurons treated with 100 nM ADDLs (A), 100 nM ADDLs + 1 μM insulin (B), or 100 nM ADDLs + 1 μM insulin + 5 μM AG1024 (C). ADDL binding was detected using the NU4 anti-ADDL antibody. (D) Integrated ADDL immunofluorescence from 3 experiments using independent neuronal cultures (25 images analyzed per experimental condition per culture). Pound sign indicates statistically significant (#, P < 0.001) difference relative to ADDL-treated cultures. Asterisk indicates statistically significant (*, P < 0.007) differences relative to cultures treated with ADDLs + insulin.