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. Author manuscript; available in PMC: 2010 Feb 20.
Published in final edited form as: Neurosci Lett. 2008 Dec 24;451(2):124–128. doi: 10.1016/j.neulet.2008.12.031

Fig. 2.

Fig. 2

PS1-D257A expression in DRG neurons prolongs SOCE. (A) Representative trace showing protocol used to study SOCE in rat DRG neurons. Treatments were applied at the times indicated by the horizontal bars. Cells were bathed in 1.26 mM Ca2+ except where indicated. The boxed region contains the SOCE response induced by returning Ca2+ to the extracellular solution. (B) Representative SOCE traces from Sham (n=6) and PS1-D257A (n=6) expressing cells are shown for the time indicated by the boxed region in A. (C) Bar graph summarizes the effects of PS1-D257A expression on [Ca2+]i for PS1-D257A and Sham transfected cells at the times listed. The letters in parentheses correspond to the times indicated in A. *p<0.05 versus Sham. (D) Bar graph shows time to recover to 75 % of the peak SOCE in Sham and PS1-D257A expressing neurons. *p<0.05, PS1-D257A versus sham.