Figure 3.

Group differences in regional gray matter. Regional gray matter differences between the group of patients with alleles associated with chromosome 8 schizophrenia (SZ8) and their matched controls (CON8) and between the group of patients with schizophrenia but none of the alleles associated with chromosome 8 schizophrenia (SZ0) and their matched controls (CON0). Separate T contrasts were used to test for differences between SZ8 and CON8 and between SZ0 and CON0. These analyses were constrained using masking to regions showing a significant main effect of schizophrenia. Group data are plotted on axial sections of a normalized template brain scan. Regions showing significant differences (P<.05, corrected) between SZ8 and CON8 subjects are depicted in red, and those between SZ0 and CON0 subjects are shown in blue. The axial sections highlight the different patterns of regional gray matter volume deficit associated with these 2 schizophrenic groups; the orbitofrontal deficits in SZ8 patients and the temporal polar and hippocampal deficit in the SZ0 patients are labeled. The distance anterior in millimeters (y coordinate) from the anterior commissure is given in the bottom left corner of each section. ofc indicates orbitofrontal cortex; tp, temporal pole; and hc, hippocampus.