Table 1.

Minimal inhibitory concentrations (μg/ml) of aminoglycoside antibiotics

Aminoglycoside	A-site rRNA
	Bacteriala	Mitochondrial (mt) hybrid	mt A1555G hybrid	mt C1494T hybrid
Neomycin B	0.5	16–32	8	8
Paromomycin	1	> 1,024	256–512	256–512
Kanamycin A	1	256–512	16–32	16
Tobramycin	1	128	16	16
Amikacin	0.5	32–64	2–4	2–4
Gentamicin	1	64–128	16–32	16–32
Netilmicin	2	512–1024	64	64–128

^aM. smegmatis wild-type rRNA