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Expression of CD274 in ALK+TCL tissues. Section of lymph nodes were examined microscopically using an intermediate (100×, large images) and high (500 and 400×, insets) power magnification. (A) H&E showed a predominance of large, frequently highly atypical cells. Immunohistochemical examination revealed strong, selective staining of the atypical cells by both anti-ALK (B) and anti-CD274 antibodies (C). The depicted images are representative for the 18 ALK+TCL cases examined.
