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. 2008 Dec 16;105(52):20852–20857. doi: 10.1073/pnas.0810958105

Fig. 3.

Fig. 3.

Expression of CD274 is induced by NPM/ALK. (A) Expression of CD274 mRNA in the ALK+TCL SUDHL-1 cell line before and after treatment with 175 nM of the ALK inhibitor CEP-14083 or its structural analog, CEP-11988, noninhibitory for ALK (ALK non-inh) (14). (B) Expression of CD274 protein in the depicted ALK+TCL cell lines before and after treatment with the ALK inhibitor CEP-14083. Treatment of the SUDHL-1 cell line with the ALK noninhibitory analog CEP-11988 served as a control (lane two). (C) Expression of CD274 examined by flow cytometry in the IL-3-dependent BaF3 cells transfected with the intact, enzymatically active NPM/ALK, kinase-activity negative K210R NPM/ALK mutant (ALK-KN), or empty vector after culture for 48 h in medium with IL-3 or without IL-3 (-).