Table 1.

Serum IgG antibody levels in ENU2 mice, 21 days after the first of 3 (days 1, 4, and 8) s.c. bolus injections of 1 I.U. of each of the indicated formulations

Formulation	Antibody (IgG) titer, dilution factor; median/range
Vehicle	50/50–50
Rt-p.R91K-PAL	12,500/6,250–506,250
PEGylated 1:8 Nektar-Rt-p.R91K-PAL	36,450/12150–109,350
PEGylated 1:1 NOF-Rt-p.R91K-PAL	8,100/450–12,150
PEGylated 1:2 NOF-Rt-p.R91K-PAL	900/150–4,050
PEGylated 1:3 NOF-Rt-p.R91K-PAL	100/50–450
PEGylated 1:4 NOF-Rt-p.R91K-PAL	40,198/36,450–109,350
PEGylated 1:8 NOF-Rt-p.R91K-PAL	900/50–1,350

n = 6.