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. 2008 Dec 15;105(52):20976–20981. doi: 10.1073/pnas.0810119105

Fig. 4.

Fig. 4.

A heterozygote of a deficiency line lacking 1 copy of DC0 improves ARM. Expressing PKA in the MBs restores normal memory to a DC0/+ mutant. (A) Total and cold shock-resistant 3-h memory are both increased by similar amounts in a Df(2L)γ7/+ line, which lacks 1 copy of DC0, compared with wild type (P < 0.0001 as assayed by t test). n = 6. (B) Twenty-four-hour memory after massed training is also significantly increased in Df(2L)γ7/+ flies (P = 0.0004 as assayed by t test). n = 14. (C) Expressing a DC0 transgene specifically in the MBs reverts the improved memory of DC0B3/+ back to the wild type. DC0B3/201y and DC0B3/c747 are a DC0B3/+ lines containing the specified MB drivers, 201y and c747, alone. DC0B3/+;PKAc/+ is a DC0B3/+ line containing a DC0 transgene in the absence of a driver, and DC0B3/201y;PKAc/+ and DC0B3/c747;PKAc/+ express the DC0 transgene under 201y and c747 control. One-way ANOVA demonstrates significant differences in 24-h memory caused by genotype in both experiments (P = 0.0045 and P = 0.0002). Bonferroni post hoc analyses show that there are no significant differences between DC0B3/+, DC0B3/201y, DC0B3/c747, and DC0B3/+;PKAc/+ lines (P > 0.05), whereas there are significant differences between DC0B3/+ and wild-type, DC0B3/201y;PKAc/+, and DC0B3/c747;PKAc/+ lines (P < 0.05). n ≥6. *, P < 0.05; ***, P < 0.001; N.S., not significant.