Table 1.
Structure of lipid-antimicrobial complexes with hexanol
| Lipid Composition (DOPG/DOPE/DOPC) | Lipid Only | Hexanol:Lipid 3:1 |
|---|---|---|
| 20/80/00 | HII | HII |
| 20/64/16 | HII | HII |
| 20/56/24 | Unilamellar Vesicle | Im3m |
| 20/48/32 | Unilamellar Vesicle | Im3m |
| 20/20/60 | Unilamellar Vesicle | Unilamellar Vesicle |
| 20/00/80 | Unilamellar Vesicle | Unilamellar Vesicle |
Hexanol decreases the membrane bending modulus and can be used to drive phase transitions into nonlamellar phases without changing intrinsic curvature. The addition of hexanol does not result in an HII phase without PE. However, at finite PE concentrations, addition of hexanol can produce a precursor Im3m phase with negative Gaussian curvature, which is topologically required for pore formation. All samples have A/L = 1/14.