. Author manuscript; available in PMC: 2009 Sep 1.

Published in final edited form as: Gastroenterology. 2008 Jun 12;135(3):770–780. doi: 10.1053/j.gastro.2008.06.033

Table 3.

Relative risk of colon cancer according to p53 status and baseline vitamin B6 intake, among 88,691 women from the Nurses' Health Study with 399 colon cancer cases^¶.

		Energy-adjusted vitamin B₆ intake, mg/day					P _trend^‡
		Q1	Q2	Q3	Q4	Q5
		≤1.30	1.31-1.60	1.61-2.00	2.01-3.50	≥3.51
All cancer
	No. cases / Person-years	95 / 375526	77 / 372929	73 / 374308	69 / 371263	85 / 367890
	Age-adjusted RR (95% CI)	1.0	0.75 (0.56-1.02)	0.65 (0.48-0.88)	0.64 (0.47-0.87)	0.77 (0.57-1.03)	0.45
	Multivariate RR (95% CI)*	1.0	0.76 (0.56-1.03)	0.68 (0.49-0.94)	0.69 (0.49-0.98)	0.88 (0.62-1.24)	0.27
p53-positive cancer^†
	No. cases / Person-years	48 / 375571	22 / 372971	20 / 374358	25 / 371298	28 / 367940
	Age-adjusted RR (95% CI)	1.0	0.43 (0.26-0.71)	0.35 (0.21-0.60)	0.46 (0.28-0.74)	0.50 (0.31-0.80)	0.15
	Multivariate RR (95% CI)*	1.0	0.43 (0.26-0.71)	0.37 (0.22-0.63)	0.50 (0.30-0.82)	0.57 (0.35-0.94) ^**	0.45
p53-negative cancer^†
	No. cases / Person-years	47 / 375566	55 / 372944	53 / 374322	44 / 371283	57 / 367915
	Age-adjusted RR (95% CI)	1.0	0.92 (0.62-1.36)	0.96 (0.65-1.42)	0.82 (0.54-1.24)	1.04 (0.70-1.53)	0.95
	Multivariate RR (95% CI)*	1.0	0.91 (0.61-1.35)	1.00 (0.67-1.50)	0.89 (0.58-1.39)	1.19 (0.78-1.83) ^**	0.44

^‡

P for trend from Wald statistic, modeling log-transformed vitamin B₆ continuously

^**

P for heterogeneity of the association for vitamin B₆ intake and p53-positive colon cancer and vitamin B₆ intake and p53-negative colon cancers = 0.011 (χ² = 13.09, 4 d.f.)