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A diagrammatic summary of a working model of TAG1-APP signaling. TAG1 is a ligand for APP. When TAG1 binds to APP this stimulates or facilitates ectodomain shedding by α- or β-secretases. Once the ectodomain has been shed, γ-secretase cleavage of the membrane bound stub can proceed. Thus, TAG1 binding leads to γ-secretase-dependent cleavage releasing ACID intracellularly. AICD interacts with the scaffolding protein, Fe65. This results in an Fe65-dependent suppression of neurogenesis.
