TABLE 1.

Structures and primary antagonism and agonism screening data for PHL library 11 in V. fischeri (Δ-luxI)

^aStrain: V. fischeri ES114 (Δ-luxI). Luminescence data measured in relative light units and normalized to OHHL (1, red). Control compounds shown in blue. All assays performed in triplicate; error did not exceed ±10% of the mean.

^bScreen performed using 5 µM synthetic ligand against 5 µM OHHL (1).

^cScreen performed using 200 µM ligand.

^dPHL 11n displayed 115% activation in this assay.